Study on Potential Mechanism of the Seed of Draba nemorosa Based on Network Pharmacology
- VernacularTitle:基于网络药理学的葶苈子潜在作用机制研究
- Author:
Peiyu SHI
1
;
Jian LIN
1
;
Guoming CHEN
1
;
Caishan FANG
1
;
Xiangjun QI
1
;
Yingyue HOU
1
;
Dongqiang LUO
1
;
Wanli XING
1
;
Ruilan HUANG
1
;
Wenting LUO
2
Author Information
1. The First School of Clinical Medicine，Guangzhou University of TCM，Guangzhou 510405，China
2. National Clinical Research Center for Respiratory Disease，the First Affiliated Hospital of Guangzhou Medical University，Guangzhou 510120，China
- Publication Type:Journal Article
- Keywords:
Seed of Draba nemorosa;
Network pharmacology;
Pharmacological effect;
Mechanism;
Effective components;
Target protein;
Signaling pathway
- From:
China Pharmacy
2019;30(20):2823-2828
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To investigate the potential pharmacological mechanism of the seed of Draba nemorosa， and to provide reference for further development， utilization and clinical application. METHODS： Effective components and related target proteins of D. nemorosa were screened and identified by using TCMSP and STRING database. Cytoscape 3.7.0 software was used to construct a visual network of effective components and target proteins for the seed of D. nemorosa， and the network topology analysis was performed. The targeting protein-protein interaction （PPI） network was constructed and analyzed by STRING database and Cytoscape 3.7.0 software. KEGG pathway enrichment of target proteins was analyzed by DAVID bioinformatics resource database. RESULTS： A total of 9 effective components were screened from the seed of D. nemorosa， including quercetin， kaempferol， β-sitosterol， etc. Totally 174 target proteins were obtained， mainly including PTGS2， NCOA2， PGR， etc. Among them， JUN and MAPK1 were core proteins in PPI network. KEGG enrichment pathway included PI3K/Akt signaling pathway， TNF-α signaling pathway， HIF-1 signaling pathway， Toll-like receptor signaling pathway and thyroid hormone signal pathway， etc. CONCLUSIONS： Effective components from the seed of D. nemorosa such as quercetin， kaempferol and β-sitosterol may act on PTGS2， JUN and MAPK1 target proteins through PI3K-Akt signaling pathway and TNF-α signaling pathway， thus exert the effects of purging lung， relieving asthma， promoting edema and reducing edema.
