Preparation and Quality Evaluation of Zingiber officinale Oil Microcapsules
- VernacularTitle:生姜油微囊的制备及其质量评价
- Author:
Xianzhe FAN
1
;
Fulin HE
1
,
2
;
Xiaowen LIU
1
,
2
;
Jingkun LYU
3
;
Xiaoming CHEN
1
,
2
Author Information
1. School of Chemistry and Bioengineering，Hunan University of Science and Engineering，Hunan Yongzhou 425100，China
2. Hunan Provincial Engineering Research Center for Ginkgo Folium，Hunan University of Science and Engineering，Hunan Yongzhou 425100，China
3. Hunan HENGWEI Pharmaceutical Co.，Ltd.，Hunan Yongzhou 425100，China
- Publication Type:Journal Article
- Keywords:
Zingiber officinale oil;
Microcapsule;
Spray drying method;
Encapsulation efficiency;
Preparation technology;
Quality evaluation
- From:
China Pharmacy
2019;30(21):2920-2925
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To prepare Zingiber officinale oil microcapsules and to evaluate its quality. METHODS： Z. officinale oil microcapsules were prepared by spray drying method with sodium starch octenyl succinate as capsule material. The preparation technology was optimized by orthogonal test with mixing temperature of capsule material and capsule core， mass ratio of capsule material and capsule core， stirring speed as factors， using encapsulation efficiency as index. The drug loading， encapsulation efficiency， appearance， particle size distribution and stability of light， heat and humidity （using iodine value and peroxide value as indexes） were evaluated. RESULTS： The optimal preparation technology of Z. officinale oil microcapsules was that the mixing temperature of capsule material and core was 60 ℃； mass ratio of capsule material and capsule core was 10 ∶ 1； stirring speed was 12 000 r/min. Average drug-loading amount and encapsulation efficiency of Z. officinale oil microcapsules prepared by optimal technology were 17.97％ and 73.57％ （n＝3）. The morphology of Z. officinale oil microcapsules was round， smooth， non-sticky and uniform in size distribution. The average diameter of microcapsules was （6.30±0.27） μm. Under light， heat and humidity conditions， the iodine value and peroxide value of Z. officinale oil microcapsules changed slightly. CONCLUSIONS： The optimal preparation technology of Z. officinale oil microcapsules is simple and reproducible. The prepared microcapsules have good encapsulation efficiency， high drug loading amount and good stability.
