Meta-analysis of Effectiveness and Safety of Xingpi Yang ’er Granules Combined wit h Clostridium butyricum Live Powder in the Treatment of Pediatric Dyspeptic Diarrhea
- VernacularTitle:醒脾养儿颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻有效性与安全性的Meta分析
- Author:
Mingxing LYU
1
;
Liyi YUAN
2
;
Yuanyuan ZENG
2
;
Yuantang XI
1
;
Liqing WANG
3
Author Information
1. First School of Clinical Medicine，Guangzhou University of TCM，Guangzhou 510405，China
2. Second School of Clinical Medicine，Guangzhou University of TCM，Guangzhou 510405，China
3. Dept. of Pediatrics，the First Affiliated Hospital of Guangzhou University of TCM，Guangzhou 510405，China
- Publication Type:Journal Article
- Keywords:
Xingpi yang’er granules;
Clostridium butyricum live powder;
Pediatric dyspeptic diarrhea;
Therapeutic efficacy;
Safety;
Meta-analysis;
Trial sequential analysis
- From:
China Pharmacy
2019;30(22):3132-3137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To systematically evaluate the effectiveness and safety of Xingpi yang’er granules（XYG） combined with Clostridium butyricum live powder （CBLP） in the treatment of pediatric dyspeptic diarrhea， and provide evidence-based reference for clinical medication. METHODS： Retrieved from Cochrane Library， PubMed， Embase， CBM， CNKI， VIP and Wanfang database， randomized controlled trials （RCTs） about XYG combined with CBLP（trial group）vs. CBLP alone（control group）in the treatment of pediatric dyspeptic diarrhea were collected. After literature screening， data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0 bias risk evaluation tool， Meta-analysis was performed by using Rev Man 5.3 software. TSA 0.9 software was used for trail sequential analysis. RESULTS： A total of 8 RCTs with 857 participants were included. Total response rate of trial group [RR＝1.20，95％CI（1.13，1.28），P＜0.000 01] was significantly higher than that of control group. Abdominal pain relief time [MD＝－1.18，95％CI（－1.42，－0.94），P＜0.000 01]， abdominal distension relief time [MD＝－1.32， 95％CI（－1.94，－0.70），P＜0.000 1]， diarrhea relief time [MD＝－2.07， 95％CI（－2.38，－1.76），P＜0.000 01]， the time of stool traits returned to normal[MD＝－2.16，95％CI（－2.43，－1.88）， P＜0.000 01] in trial group were significantly shorter than control group. The stool frequency [MD＝－1.72，95％CI（－2.18，－1.24）， P＜0.000 01] in trial group were significantly less than control group. The incidence of ADR in trial group was significantly lower than control group （P＜0.05）， or there was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）， or no significant ADR was founded in 2 groups. Trial sequential analysis showed that the evidence of total response rate of XYG combined with CBLP in the treatment of pediatric dyspeptic diarrhea was accurate. CONCLUSIONS： XYG combined with CBLP is effective and safe for pediatric dyspeptic diarrhea.
