Study on Diterpenoid Alkaloids in Aconitum carmichaeli from Guizhou Province
- VernacularTitle:黔产乌头的二萜生物碱类成分研究
- Author:
Tianpeng YIN
1
;
Zhihui LUO
1
;
Min WANG
1
;
Ze WANG
1
Author Information
1. Zhuhai Campus of Zunyi Medical University & Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine，Guangdong Zhuhai 519041，China
- Publication Type:Journal Article
- Keywords:
Aconitum carmichaeli;
Constituents;
Diterpenoid alkaloids;
NMR;
MS;
Identification
- From:
China Pharmacy
2019;30(22):3096-3100
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To study the diterpenoid alkaloids in Aconitum carmichaeli from Guizhou province， and to provide reference for the further enrichment of chemical constituents of plants from the genus Aconitum and the development and utilization of A. carmichaeli from Guizhou province. METHODS： The root tuber of A. carmichaeli from Guizhou province was collected. The total alkaloids of A. carmichaeli roots were extracted by acid extraction and alkali precipitation method. The diterpenoid alkaloids were obtained by isolating and purifying total alkaloids extract with silica gel column chromatography. The structures of the isolated compounds were elucidated on the basis of NMR and MS analysis. RESULTS & CONCLUSIONS： Fifteen diterpenoid alkaloids， including 12-epi-15-O-acetyl-17-benzoyl-16-hydroxy-16，17-dihydronapelline（Ⅰ），songorine（Ⅱ），songoramine（Ⅲ），10-aconifine（Ⅳ），hypaconitine（Ⅴ），deoxyaconitine（Ⅵ），aconitine（Ⅶ），mesaconitine（Ⅷ），14-benzoyltalasamine（Ⅸ），talatisamine（Ⅹ），neoline（ⅩⅠ），6-epi-chasmanine（ⅩⅡ），isotalatizidine（ⅩⅢ），sachaconitine（ⅩⅣ）and kalakoline（ⅩⅤ） were identified form A. carmichaeli roots from Guizhou Province. Compounds Ⅸ and ⅩⅡ were isolated from this specie for the first time.
