Investigation and Analysis of the Prescriptions of Outpatient/Emergency Microecological Preparations in 5 Children’s Hospitals
- VernacularTitle:5家儿童医院门/急诊微生态制剂处方调查分析
- Author:
Ting WEI
1
;
Xiaoling WANG
2
;
Yan JIN
1
;
Jinjing MA
2
;
Ailing QUE
3
;
Juping WANG
4
;
Limei HE
5
Author Information
1. Dept. of Pharmacy，Harbin Children’s Hospital，Harbin 150010，China
2. Dept. of Pharmacy，Beijing Children’s Hospital Affiliated to the Capital Medical University，Beijing 100045，China
3. Dept. of Pharmacy，Jiangxi Provincial Children’s Hospital，Nanchang 330006，China
4. Dept. of Pharmacy，Henan Provincial Children’s Hospital，Zhengzhou 450018，China
5. Dept. of Pharmacy，Hunan Provincial Children’s Hospital，Changsha 410007，China
- Publication Type:Journal Article
- Keywords:
Microecological preparation;
Children;
Off-label drug use;
Prescription analysis
- From:
China Pharmacy
2019;30(23):3276-3280
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To investigate the situation and problems of clinical microecological preparations in pediatrics department of China， and to provide reference for rational application of microecological preparations in children. METHODS： Outpatient/emergency prescriptions of microecological preparations during Jan.-Mar. 2019 were retrieved from information system of 5 “Third Grade Class A” children hospitals， and were investigated and analyzed in respects of the type of microecological agents， age distribution， clinical diagnosis， drug combination， off-label medication， etc. RESULTS： A total of 74 210 outpatient/emergency prescriptions were collected， involving 18 kinds of microecological preparations. Among them， Clostridium butyricum combined viable powder ranked first （31 146， accounting for 41.97％）， followed by Brucella yeast powder （14 289， accounting for 19.25％） and Compound Lactobacillus acidophilus tablets （10 281， 13.85％）. The age of children was less than 18 years old， and the proportion of children aged 1-＜3 years old was the highest （33 753， 45.48％）. The most common clinical diagnosis was digestive tract diseases （54 009， 72.78％）， followed by respiratory infectious diseases （11 744， 15.83％）. In combination with microecological agents， there were Chinese patent medicine for invigorating the spleen and stomach （18 546， 24.99％）， antibacterial medicine （10 595， 14.28％） and oral rehydration salt Ⅲ （8 238， 11.10％）. Off-label drug use was found in 19 532 prescriptions （26.32％）， mainly manifesting as super-indications （15 590， 21.01％）， super-usage and dosage （8 098， 14.52％）， super crowd medication （48， 3.91％） was found in a few prescriptions. CONCLUSIONS： There is a high incidence of off-label use of microecological agents in children. Medical staff should standardize prescription behavior and promote rational use of drugs. At the same time， the improvement of the information of children’s medication in drug instructions to ensure the safety and effectiveness of children’s medication should be encouraged.
