Effects of ADRB2（rs1042713）Gene Polymorphism on Therapeutic Efficacy of Anticholinergic Drugs in the Treatment of Refractory Asthma Pediatric Patients
- VernacularTitle:ADRB2（rs1042713）基因多态性对抗胆碱能药物治疗难治性哮喘患儿疗效的影响
- Author:
Danyang REN
1
;
Caixia TU
1
;
Huiying LI
1
;
Yunwei LI
1
;
Ming LI
2
;
Dongmei YE
2
;
Jianling SHEN
1
;
Pin GUO
1
;
Yuanli LI
3
;
Tao XU
4
;
Quan ZHANG
2
Author Information
1. Dept. of Pharmacy，Children’s Hospital of Kunming Medical Unive rsity，Kunming 650228，China
2. Dept. of Respiration，Children’s Hospital of Kunming Medical Unive rsity，Kunming 650028，China
3. School of Pharmacy，Haiyuan College，Kunming Medical Unive rsity，Kunming 650106，China
4. School of Pharmacy，Anhui Medical University，Hefei 230032，China
- Publication Type:Journal Article
- Keywords:
Refractory asthma;
ADRB2（rs1042713）;
Gene polymorphism;
Anticholinergic drug;
Children
- From:
China Pharmacy
2019;30(23):3265-3270
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To study the effects of ADRB2 （rs1042713） gene polymorphism on therapeutic efficacy of anticholinergic drug in the treatment for refractory asthma pediatric patients. METHODS： 171 children with refractory asthma were selected from outpatient department of Kunming Children’s Hospital during Nov. 2016 to Jul. 2019. The distribution of ADRB2 （rs1042713） genotype， the clinical efficacy [asthma control test （C-ACT） score， FEV1， FVC， PEF， maximal mid-expiratory flow （MMEF）] of anticholinergic drug were analyzed statistically； the response of different genotypes to the use of anticholinergic drug were also analyzed statistically. RESULTS： 148 of 171 refractory asthmatics pediatric patients were administered anticholinergic drug， among them 50 of the 71 AA genotype and 36 of the 77 GA genotype responded to anticholinergic drug treatment. Statistical analysis showed that 71 children with AA refractory asthma had improved C-ACT score， FEV1， FVC， PEF and MMEF， there was statistical significance， compared with GA genotype （P＜0.05）； the response rate of the AA genotype to anticholinergic drugs was 2.71 times that of the GA genotype [OR＝2.71， 95％CI （1.38， 5.34）， P＝0.005]. CONCLUSIONS： The detection of ADRB2 （rs1042713） gene polymorphism has some guiding significance in the treatment of refractory asthma with anticholinergic drugs， and the response of AA genotype is better.
