Clinical characteristics related to onset age of wheeze in school-age children and adolescents with asthma.
10.4168/aard.2015.3.5.326
- Author:
Gwang Cheon JANG
1
;
Jung Yeon SHIM
;
Young Min AHN
;
Jin A JUNG
;
Sung Won KIM
;
Hai Lee CHUNG
Author Information
1. Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Asthma;
Child;
Adolescent
- MeSH:
Adolescent*;
Age of Onset*;
Asthma*;
Busan;
Child*;
Daegu;
Demography;
Dermatophagoides pteronyssinus;
Forced Expiratory Volume;
Gyeonggi-do;
Hospitalization;
Humans;
Hypersensitivity;
Lung;
Methacholine Chloride;
Prevalence;
Respiratory Function Tests;
Seoul;
Smoking
- From:Allergy, Asthma & Respiratory Disease
2015;3(5):326-333
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We aimed to investigate the clinical characteristics and their relationship with the onset age of wheeze in school-age children and adolescents with asthma. METHODS: Three hundred twenty-six patients, aged 6 to 19 years, diagnosed with asthma at 6 hospitals from Seoul, Gyeonggi, Daegu, and Busan were enrolled. They were categorized into 3 groups by the onset age of wheeze: group A, early onset (age <3 years); group B, preschool onset (age 3-6 years); group C, late onset (age > or =6 years). Clinical characteristics including atopic sensitization, family history, combined allergic diseases, severity of asthma, and influence of asthma on daily life were examined. A history of hospitalization for early lower respiratory infection (LRI) and environmental tobacco smoking were studied and lung function tests were also performed. RESULTS: There was no difference in demographics, prevalence of atopy, combined allergic diseases, and family history of allergy between 3 groups. A history of sever LRI in early life was more common in groups A and B compared with group C. Sensitization to Dermatophagoides pteronyssinus was more prevalent in groups A and B than in group C. Forced expiratory flow between 25% to 75% (FEF(25%-75%)) was lower in groups A and B than in group C, and methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second) was lowest in group B. Significantly lower FEF(25%-75%) and methacholine PC20 were observed in the patients who had been hospitalized with LRI in early life. CONCLUSION: Our study shows significant difference in lung function and atopic sensitization in relation to the onset age of wheeze in school-age children and adolescents with asthma, and suggests that early LRI might contribute to the development of asthma in early life.
