Bayesian Network Meta-analysis of Therapeutic Efficacy of Xianling Gubao Capsules Combined with Routine Therapy for Postmenopausal Osteoporosis
- VernacularTitle:仙灵骨葆胶囊联合常规疗法用于绝经后骨质疏松症疗效的贝叶斯网状Meta分析
- Author:
Xiangjun ZENG
1
;
Jiena CHEN
2
;
Huaqing JIANG
2
;
Chushuo SHI
2
,
3
;
Hongyu TANG
4
;
Chi ZHOU
4
;
Haibin WANG
4
Author Information
1. Guangzhou Orthopaedics Hospital Affiliated to Guangzhou University TCM/ Guangzhou Orthopaedics Hospital，Guangzhou 510405，China
2. Guangzhou University of TCM，Guangzhou 510405，China
3. Dept. of Cardiovascular Disease，the First Affiliated Hospital of Guangzhou University TCM，Guangzhou 510405，China
4. Hip-preserving Ward，the First Affiliated Hospital of Guangzhou University TCM，Guangzhou 510405，China
- Publication Type:Journal Article
- Keywords:
Xianling gubao capsules;
Postmenopausal osteoporosis;
Therapeutic efficacy;
Bayesian network Meta-analysis
- From:
China Pharmacy
2019;30(18):2556-2562
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To systematically evaluate the difference of therapeutic efficacy of Xianling gubao capsules combined with routine therapy for postmenopausal osteoporosis （PMOP）. METHODS： Retrieved from Cochrane Library， PubMed， Embase， ClinicalTrials， CNKI， VIP， Wanfang database and CBM， clinical randomized controlled trials （RCTs） about Xianling gubao capsules combined with placebo and routine treatment （trial group） versus placebo and routine treatment or Xianling gubao capsules （control group） alone in the treatment of PMOP were collected. After literature screening and data extraction， the quality of included literatures were evaluated with Cochrane system evaluator manual 5.3 recommend bias risk evaluation tool. Bayesian Network Meta-analysis was performed with Stata 14.0 software and Bayesian Markov Chain Monte Carlo. RESULTS： A total of 16 RCTs were included， involving a total of 1 360 patients and 3 intervention measures as Xianling gubao capsules alone， Xianling gubao capsules combined with routine treatment， routine treatment. Results of Meta-analysis showed that in respect of improving total response rate， compared with routine treatment， Xianling gubao capsules combined with routine treatment [OR＝0.28，95％CI（0.12， 0.64），P＜0.05]could significantly improve total response rate； network Meta-analysis ranking showed that Xianling gubao capsules combined with routine treatment＞Xianling gubao capsules alone＞routine treatment. In terms of increasing bone mineral density （BMD）， compared with routine treatment， Xianling gubao capsules combined with routine treatment [OR＝0.45，95％CI（0.24， 0.84），P＜0.05] and Xianling gubao capsules alone [OR＝0.78， 95％CI（0.32， 0.84），P＜0.05] could significantly improve BMD； network Meta-analysis ranking showed that Xianling gubao capsules combined with routine treatment＞Xianling gubao capsules alone＞routine treatment. In the term of improving serum calcium level， compared with Xianling gubao capsules alone [OR＝4.76，95％CI（2.14， 10.59），P＜0.05] and routine treatment [OR＝0.45， 95％CI（0.21， 0.99），P＜0.05]， Xianling gubao capsules combined with routine treatment could significantly improve serum calcium level； network Meta-analysis ranking showed that Xianling gubao capsules combined with routine treatment＞routine treatment＞Xianling gubao capsules alone. In the term of improving serum phosphorus level， compared with Xianling gubao capsules alone， Xianling gubao capsules combined with routine treatment [OR＝2.85，95％CI（1.81， 4.48），P＜0.05] and routine treatment [OR＝2.93，95％CI（1.76， 4.86），P＜0.05] could significantly improve serum phosphorus level； network Meta-analysis ranking showed that routine treatment＞Xianling gubao capsules combined with routine treatment＞Xianling gubao capsules alone. CONCLUSIONS： Xianling gubao capsules combined with routine treatment can significantly improve therapeutic efficacy of PP patients， increase BMD and serum calcium level after treatment， but routine treatment is the best in improving serum phosphorous level.
