Optimization of the Ultrasound Extraction Technology of Jinjuan Shengban Capsules by Response Surface Methodology Combined with Multi-index Comprehensive Scoring
- VernacularTitle:多指标综合评分结合响应面法优选金卷升板胶囊的超声提取工艺
- Author:
Lingjiao WANG
1
;
Xian GAO
2
;
Qingchi LIU
3
;
Jizhang YANG
1
;
Guoxiang SUN
4
;
Jing YU
1
Author Information
1. Dept. of Pharmacy，the First Hospital of Hebei Medical University，Shijiazhuang 050031，China
2. Dept. of Wise Information Technology of 120，the First Hospital of Hebei Medical University，Shijiazhuang 050031，China
3. Dept. of Hematology，the First Hospital of Hebei Medical University，Shijiazhuang 050031，China
4. College of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China
- Publication Type:Journal Article
- Keywords:
Jinjuan shengban capsules;
Multi-index comprehensive scoring;
Response surface method;
Ultrasonic extraction;
Optimization of technology
- From:
China Pharmacy
2019;30(13):1781-1786
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To optimize the ultrasonic extraction technology for Jinjuan shengban capsules. METHODS： Using comprehensive score of indexes as transfer rate of gallic acid， chlorogenic acid， baicalin， aloe emodin and emodin methyl ether， with ethanol volume fraction， ultrasonic power， ultrasonic extraction time and liquid-material ratio as factors， the ultrasound extraction technology of Jinjuan shengban capsules was optimized by Box-Behnken response surface methodology based on single factor test. The validation test was conducted. RESULTS： The best extraction technology was 50-fold 70％ ethanol， extracting 40 min under 300 W. In validation test， average transfer rates of gallic acid， chlorogenic acid， baicalin， aloe emodin and emodin methyl ether were 85.92％， 86.37％， 92.76％， 90.84％ and 87.26％ （RSD＜3.57％，n＝3） in 3 batches of samples； comprehensive score was 88.95％， relative error of which to predicted value of 88.27％ was 1.10％. CONCLUSIONS： The response surface method combined with multi-index comprehensive scoring can be used to optimize the extraction technology of Jinjuan shengban capsules which is simple and stable.
