Optimization of Water Extraction Technology of Taohe Chengqi Decoction by Response Surface Methodology Combined with Information Entropy Theory
- VernacularTitle:响应面法结合信息熵理论优化桃核承气汤水提取工艺
- Author:
Jiaying DUN
1
;
Peng ZHENG
1
;
Jiajia LI
2
;
Yao MA
1
;
Chunhua LI
1
Author Information
1. Teaching and Research Section of Pharmacy，College of Pharmacy，Hebei University of Traditional Chinese Medicine，Shijiazhuang 050090，China
2. Dept. of Pharmacy，Shijiazhuang Forth Hospital，Shijiazhuang 050011，China
- Publication Type:Journal Article
- Keywords:
Taohe chengqi decoction;
Response surface methodology;
Information entropy theory;
Comprehensive score;
Water extraction technology;
Technology optimization
- From:
China Pharmacy
2019;30(16):2210-2215
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To optimize the water extraction technology of classic formula Taohe chengqi decoction. METHODS： Based on single factor test， combined with response surface methodology and information entropy theory， the soaking time， solid-liquid ratio and extraction time were investigated. Using the contents of rhein， amygdalin， cinnamaldehyde and glycyrrhizic acid in Taohe chengqi decoction as indexes， information entropy theory was used to assign weight coefficients to each evaluation index and calculate the comprehensive score. Through Design-Expert 10 software， the interactions of each factor were analyzed. Water extraction technology was optimized， and validation test was also performed. RESULTS： According to information entropy theory， the weight coefficients of rhein， amygdalin， glycyrrhizic acid and cinnamaldehyde were located at 0.097 6， 0.363 2， 0.173 5 and 0.365 7. The results of interaction analysis showed that the material-liquid ratio had a greater impact on the comprehensive score. The optimal water extraction technology of Taohe chengqi decoction were determined as that soaking time was 60 min； the ratio of material to liquid was 1 ∶ 10 （g/mL）； total extraction time was 130 min （extracting for 3 times， lasting for 65， 33， 32 min each time）. The results of verification test showed that RSD of content of each index component and the comprehensive score was less than 3％. CONCLUSIONS： The optimal water extraction technology is proved to be stable and feasible， which can provide the basis for the further development and utilization of Taohe chengqi decoction.
