Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction.
10.3349/ymj.2016.57.6.1339
- Author:
Woo Dae BANG
1
;
Kiwoong KIM
;
Yong Ho LEE
;
Hyukchan KWON
;
Yongki PARK
;
Hui Nam PAK
;
Young Guk KO
;
Moonhyoung LEE
;
Boyoung JOUNG
Author Information
1. Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. cby6908@yuhs.ac
- Publication Type:Original Article
- Keywords:
Acute myocardial infarction;
prognosis;
magnetocardiography
- MeSH:
Follow-Up Studies;
Humans;
Magnetocardiography*;
Male;
Multivariate Analysis;
Myocardial Infarction*;
Population Characteristics*;
Prognosis*
- From:Yonsei Medical Journal
2016;57(6):1339-1346
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Magnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI. MATERIALS AND METHODS: In 124 AMI patients (95 males, mean age 60±11 years), including 39 with ST-elevation myocardial infarction, a 64-channel MCG was performed within 2 days after AMI. During a mean follow-up period of 6.1 years, major adverse cardiac events (MACE) were evaluated. RESULTS: MACE occurred in 31 (25%) patients, including 20 revascularizations, 8 deaths, and 3 re-infarctions. Non-dipole patterns were observed at the end of the T wave in every patients. However, they were observed at T-peak in 77% (24/31) and 54% (50/93) of patients with and without MACE, respectively (p=0.03). Maximum current, field map angles, and distance dynamics were not different between groups. In the multivariate analysis, patients with non-dipole patterns at T-peak had increased age- and gender-adjusted hazard ratios for MACE (hazard ratio 2.89, 95% confidence interval 1.20–6.97, p=0.02) and lower cumulative MACE-free survival than those with dipole patterns (p=0.02). CONCLUSION: Non-dipole patterns at T-peak were more frequently observed in patients with MACE and were related to poor long-term prognosis. Thus, repolarization heterogeneity measured by MCG may be a useful predictor for AMI prognosis.
