Meta-analysis and Trial Sequential Analysis of Therapeutic Efficacy of Compound Xuanju Capsules Combined with Chemical Medicine versus Chemical Medicine Alone in the Treatment of Polycystic Ovarian Syndrome
- VernacularTitle:复方玄驹胶囊联合化学药对比单用化学药治疗多囊卵巢综合征疗效的Meta分析及试验序贯分析
- Author:
Yizheng ZHONG
1
;
Jiahua HUANG
1
;
Meijun PAN
1
;
Fan HUANG
2
;
Weipeng SUN
1
;
Lu ZHANG
1
;
Jing LIN
3
;
Jingjing CHEN
3
;
Pengpeng XIE
3
;
Langchi HE
3
;
Wei FAN
3
;
Kaimin GUO
3
Author Information
1. The First Clinical College，Guangzhou University of TCM，Guangzhou 510405，China
2. Clinical Medical College of Acupuncture and Moxibustion Rehabilitation，Guangzhou University of TCM，Guangzhou 510405，China
3. TCM Gynecology，Guangzhou Women’s and Children’s Medical Center，Guangzhou 510000，China
- Publication Type:Journal Article
- Keywords:
Polycystic ovarian syndrome;
Chemical medicine;
Compound xuanju capsule;
Therapeutic efficacy;
Meta- analysis;
Trial sequential analysis
- From:
China Pharmacy
2019;30(17):2404-2409
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To systematically evaluate the efficacy of Compound xuanju capsules combined with chemical medicine versus chemical medicine alone in the treatment of polycystic ovarian syndrome （PCOS）， in order to provide evidence-based medicine guidelines for clinical medication. METHODS： Retrieved from PubMed， Embase， Cochrane library， CBM， VIP， CJFD and Wanfang database from database establishment to Apr. 5， 2019， randomized controlled trials （RCTs） about therapeutic efficacy （total response rate， ovulation rate， pregnancy rate， FSH level， LH level， testosterone level， degree of endometrial thickening） of Compound xuanju capsules combined with chemical medicine （trial group） versus chemical medicine alone （control group） in the treatment of PCOS were collected. After data extraction and quality evaluation of included studies with modified Jadad scale， Meta-analysis was conducted by using STATA 14.0 software. Trial sequential analysis （TSA） was conducted by using TSA 0.9 software. RESULTS： A total of 15 RCTs were included， involving 1 259 patients. The results of Meta-analysis showed that the total response rate [RR＝1.27，95％CI（1.13，1.44），P＜0.001]， ovulation rate [RR＝1.18，95％CI（1.03，1.37），P＜0.001]， pregnancy rate [RR＝1.34，95％CI（1.11，1.61），P＜0.001]， serum hormone level {FSH [SMD＝－0.66，95％CI （－0.51， －0.82），P＜0.001]， 95％CI（－1.76，－1.41），P＜0.001]， LH [SMD＝－1.24，95％CI（－1.39， －1.08），P＜0.001]， testosterone [SMD＝－1.59，95％CI（－1.76，－1.41），P＜0.001]} and endometrial thickness [SMD＝1.20，95％CI（1.04，1.37），P＜0.001] of the trial group were better than those of the control group， with statistical significance. The results of TSA were reliable. CONCLUSIONS： In the treatment of PCOS， Compound xuanju capsules combined with chemical medicine is better than chemical medicine alone in improving total response rate， pregnancy rate， ovulation rate and endometrial thickness， and reducing serum hormone levels.
