Application of Medication Therapy Management Combined with Medicine Gene Detection in Individualized Pharmaceutical Care of An Elderly Patient with Warfarin-induced Acute Upper Gastrointestinal Hemorrhage
- VernacularTitle:药物治疗管理结合药物基因检测在1例服用华法林致急性上消化道出血的老年患者个体化药学服务中的应用
- Author:
Lan WANG
1
;
Qiantai MAO
1
;
Xiaoning ZHANG
2
;
Zhaoshuai JI
1
;
Chao AI
1
Author Information
1. Beijing Tsinghua Changgung Hospital，School of Clinical Medicine，Tsinghua University，Beijing 102218，China
2. School of Medicine，Tsinghua University，Beijing 100084，China
- Publication Type:Journal Article
- Keywords:
Warfarin;
Medication therapy management;
Medicine gene detection;
Individualized pharmaceutical care
- From:
China Pharmacy
2019;30(17):2388-2393
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To investigate how pharmacists provide through individualized pharmaceutical care for patients medication therapy management（MTM） combined with medicine gene detection， and to promote rational drug use in clinic.METHODS： A case of elderly comorbidity with acute upper gastrointestinal hemorrhage caused by Warfarin sodium tablets was taken as an example. The patient had a history of type 2 diabetes mellitus and hypertension. Coronary artery bypass grafting was performed two months before admission， and urinary tract infection occurred half a month ago. Medication therapy course was analyzed retrospectively before and after hospitalization； based on gene typing detection of CYP2C9*3 and VKORC1-1639， the individualized dose of Warfarin sodium tablets was evaluated. MTM was perfomed for acute upper gastrointestinal hemorrhage and all medication of patient to formulate individualized medication scheme. RESULTS： The genotyping of warfarin CYP2C9*3 and VKORC1-1639 indicated that the patients were of super slow metabolic type. The recommended dosage of warfarin should be 0.86-1.86 mg/d. Based on MTM analysis of acute upper gastrointestinal hemorrhage， the main causes of acute upper gastrointestinal hemorrhage were Warfarin sodium tablets 3.0 mg/d， poor drug compliance， disease status and co-morbidity and multi-drug combination. Clinical gastrointestinal hemorrhage of the patients were improved after drug withdrawal， anticoagulant drugs was changed into Rivaroxaban tablet，10 mg/d. Through MTM for all drug use in the patient， results of medication reorganization showed that Diltiazem hydrochloride tablet， Amoxicillin/clavulanate potassium dispersible tablet， Compound vitamin tablet were stopped； hypoglycemic drug Glimepiride tablet was changed into Gliquidone tablet； Metoprolol tartrate tablet was changed into Bisoprolol tablet after coronary artery bypass graft； proton pump inhibitor Esomeprazole enteric-coated tablet was changed into Pantoprazole sodium enteric-coated capsule. CONCLUSIONS： The pharmaceutical care mode of MTM combined with medicine gene detection can guide rational drug use in clinic， realize individualized pharmaceutical care， improve patient compliance and prevent problems related to adverse drug reactions.
