Preparation and Quality Evaluation of Resveratrol-Hydroxypropyl- β-Cyclodextrin-Chitosan Sustained-release Pellets
- VernacularTitle:白藜芦醇-羟丙基-β-环糊精-壳聚糖缓释微球的制备及表征
- Author:
Chungang ZHANG
1
;
Chenchen YU
1
;
Yixuan ZHOU
1
;
Li YIN
1
;
Lan CHENG
1
;
Tingguo KANG
1
;
Lan HAN
2
Author Information
1. School of Pharmacy，Liaoning University of Traditional Chinese Medicine，Liaoning Dalian 116620，China
2. School of Pharmacy，Anhui University of Traditional Chi nese Medicine，Hefei 230012，China
- Publication Type:Journal Article
- Keywords:
Resveratrol;
Hydroxypropyl-β-cyclodextrin;
Chitosan;
Preparation;
Characterization
- From:
China Pharmacy
2019;30(17):2322-2326
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To prepare Resveratrol-hydroxypropyl-β-cyclodextrin-chitosan sustained-release pellets （RES-HP-β- CD-Chitosan）， and to characterize it. METHODS： Resveratrol raw material， HP-β-cyclodextrin and chitosan were collected with ratio of 1 ∶ 7 ∶ 0.25. Resveratrol-HP-β-cyclodextrin inclusion compound were prepared by solvent method， and then added into chitosan， RES-HP-β-CD-Chitosan were prepared by spray drying method. Particle size of prepared sustained-released pellets were observed by optical microscope. X-ray， DSC， IR and SEM were used to characterize RES-HP-β-CD-Chitosan. The contents of resveratrol in prepared sustained-released pellets were determined by UV spectrum， and drug-loading amount and encapsulation efficiency were calculated. RESULTS： Particle size of prepared RES-HP-β-CD-Chitosan was （2.23±0.35） μm （n＝300）. Characterization results show that RES-HP-β-CD-Chitosan was spherical in shape； shrinkage was found on the surface of microspheres， and resveratrol was included in HP-β-cyclodextrin in molecule or amorphous state. Drug-loading amount of prepared RES-HP-β-CD-Chitosan was 11.67％ （n＝3）， encapsulation efficiency was 96.27％ （n＝3）. CONCLUSIONS： RES-HP-β-CD- Chitosan is prepared successfully.
