Efficacy and Safety of Nalbuphine for Post-operative Analgesia ：a Meta-analysis
- VernacularTitle:纳布啡用于术后镇痛有效性与安全性的Meta分析
- Author:
Chao LEI
1
;
Haiyan LIAO
1
,
2
;
Zhaohui ZHANG
1
;
Xingguang QU
1
;
Mu QIN
1
Author Information
1. The First College of Clinical Medical Sciences，China Three Gorges University/ICU of Yichang Central People’s Hospital，Hubei Yichang 443003，China
2. Medical College，China Three Gorges University，Hubei Yichang 443002，China
- Publication Type:Journal Article
- Keywords:
Nalbuphine;
Postoperative analgesia;
Efficacy;
Safety;
Meta-analysis
- From:
China Pharmacy
2019;30(4):528-532
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To evaluate the efficacy and safety of nalbuphine for postoperative analgesia systematically， and to provide evidence-based reference in clinic. METHODS： Retrieved from Embase， Medline， PubMed， CNKI， VIP and Wanfang database， RCTs about nalbuphine hydrochloride （trial group） vs. other analgesics （control group） for postoperative analgesia were collected. After literature screening， data extraction and literature quality evaluation with modified Jadad scale， Meta-analysis was performed by using Rev Man 5.3 statistical software. RESULTS： A total of 10 RCTs were included， involving 796 patients. Results of Meta-analysis showed that there was no statistical significance in satisfaction rate of analgesia [OR＝1.11，95％CI（0.70，1.74），P＝0.66]， the incidence of nausea [OR＝1.20，95％CI（0.79，1.83），P＝0.39]， vomiting [OR＝1.02，95％CI（0.69，1.50），P＝0.92] or narcolepsy [OR＝1.32，95％CI（0.47，3.76），P＝0.06] between 2 groups. The incidence of pruritus [OR＝0.29，95％CI（0.14，0.58），P＝0.000 6]， respiratory depression [OR＝0.21，95％CI（0.08，0.58），P＝0.003] and uroschesis [OR＝0.05，95％CI（0.01，0.37），P＝0.004] in trial group were significantly lower than control group. CONCLUSIONS： Nalbuphine has better efficacy and safety for postoperative analgesia.
