Analysis of the Utilization of Antidepressant Drugs in 11 Hospitals from Zhejiang Province during 2013-2017
- VernacularTitle:浙江省11家医院2013－2017年抗抑郁药使用分析
- Author:
Li WANG
1
;
Fan WU
2
Author Information
1. Dept. of Pharmacy，the Affiliated Obstetrics and Gynecology Hospital of Zhejiang University School of Medicine，Hanzhou 310006，China
2. Dept. of Pharmacy，the First Affiliated Hospital of Zhejiang University of TCM，Hanzhou 310006，China
- Publication Type:Journal Article
- Keywords:
Antidepressants;
Consumption sum;
Defined daily dose system;
Daily drug cost;
Analysis of drug use;
Zhejiang province
- From:
China Pharmacy
2019;30(5):704-707
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To investigate the application of antidepressants in Zhejiang province and to provide reference for rational drug use in clinic. METHODS： WHO-recommended defined daily dose （DDD） method was used to statistically analyze consumption sum， main types， defined daily dose system （DDDs）， daily drug cost （DDC） and ranking ratio （B/A value， i.e. consumption sum rank/DDDs rank， B/A＜1 means the price of drugs was higher， whereas the price of drugs was lower） of antidepressant drugs in 11 hospitals from Zhejiang province during 2013-2017. RESULTS： The consumption sum of antidepressants was increased year by year in 11 hospitals from Zhejiang during 2013-2017， and increased from 3 235 200 yuan in 2013 to 4 569 100 yuan in 2017； the proportion of consumption sum of antidepressants in total consumption sum of all drugs kept stable， ranging from 0.47％ to 0.50％. The top 5 drugs by consumption sum were fluoxetine， duloxetine， olanzapine and venlafaxine； consumption sum of escitalopram accounted for a larger increase （proportion ration increased from 8th place in 2013 to first place in 2017）. Within 5 years， DDDs of fluoxetine， paroxetine and sertraline took up the first 3 place； DDC of olanzapine， quetiapine and duloxetine took up the first 3 place； the drugs with B/A value＜1 included duloxetine， olanzapine， venlafaxine and quetiapine， etc； the drugs with B/A value＞1 were paroxetine and sertraline. CONCLUSIONS： The use of antidepressant drugs in 11 hospitals from Zhejiang province is rational in structure； selective 5-hydroxytryptamine （5-HT） reuptake inhibitors （SSRI）， selective 5-HT and noradrenaline reuptake inhibitor （SNRI） take up the predominant place. New antidepressant drug escitalopram shows a good clinical prospect.
