Network Pharmacology Exploration of the Mechanism of Cistanche deserticola in the Treatment of Osteoporosis
- VernacularTitle:肉苁蓉治疗骨质疏松作用机制的网络药理学研究
- Author:
Yantao WANG
1
;
Zhihua YANG
2
;
Yi CHEN
3
;
Zhexing MAI
2
;
Jiahua HUANG
3
;
Zhizhong SUN
3
;
Chi ZHOU
4
;
Weikuan LI
1
Author Information
1. General Department，Guangzhou Panyu District Hospital of TCM，Guangzhou 511400，China
2. Second Clinical Medical College，Guangzhou University of TCM，Guangzhou 510405，China
3. First Clinical Medical College，Guangzhou University of TCM，Guangzhou 510405，China
4. Hip Protection Ward，the First Affiliated Hospital of Guangzhou University of TCM，Guangzhou 510115，China
- Publication Type:Journal Article
- Keywords:
Cistanche deserticola;
Osteoporosis;
Network pharmacology;
Active ingredients;
Target;
Molecular docking;
Signaling pathways
- From:
China Pharmacy
2019;30(5):645-651
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To study the mechanism of Cistanche deserticola in the treatment of osteoporosis by network pharmacology. METHODS： The active components of C. deserticola were retrieved and obtained by TCM system platform （TCMSP）. Reverse molecular docking server DRAR-CPI and related databases GeneCards and OMIM were used to screen the target of C. deserticola active ingredients in the treatment of osteoporosis. The “component-target”network of C. deserticola was constructed by Cytoscape software， and the interaction between targets was plotted by String database and Cytoscape software. The combination activity of target and active ingredient was evaluated via molecular docking with Systems Dock WebSite server. GO classification and enrichment analysis and KEGG pathway enrichment analysis were conducted for target genes using DAVID database. RESULTS： Totally 13 active ingredients were screened out from C. deserticola， such as verbascoside， leonurine， geniposidic acid. There were 43 active ingredient-treated potential targets， such as RUNX2， VEGF， IL-6， BGP， TNF. Multiple signaling pathways were involved in target action， such as WNT （Wingless/Integrated）， VEGF， TNF. CONCLUSIONS： This study preliminarily explores and validates the main targets and pathways of C. deserticola in the treatment of osteoporosis， which lay the foundation for further study of its mechanism.
