Optimization of Water Extraction Technology of Chaihu Anxin Capsules by Box-Behnken Response Surface Method Combined with Multi-index Comprehensive Scoring Method
- VernacularTitle:Box-Behnken响应面法结合多指标综合评分法优选柴胡安心胶囊的水提工艺
- Author:
Lingjiao WANG
1
;
Yupei HAO
1
;
Kunshen LIU
2
;
Jizhang YANG
1
;
Guoxiang SUN
3
;
Jing YU
1
Author Information
1. Dept. of Pharmacy，the First Hospital of Hebei Medical University，Shijiazhuang 050031，China
2. Dept. of Cardiology，the First Hospital of Hebei Medical University，Shijiazhuang 050031，China
3. College of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China
- Publication Type:Journal Article
- Keywords:
Chaihu anxin capsules;
Active ingredients;
Box-Behnken response surface method;
Multi-index;
Comprehensive scoring;
Water extraction technology;
Optimization
- From:
China Pharmacy
2019;30(5):632-637
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To optimize the water extraction technology of Chaihu anxin capsules. METHODS： Taking comprehensive scoring value of the contents of gallic acid，chlorogenic acid，puerarin，glycoside，rutin，cinnamic acid， quercetin and the yield of extract as investigation index， using multiple of adding liquid， soaking time， reflux time and extraction times as factors， water extraction technology of Chaihu anxin capsule was optimized by Box-Behnken response surface method based on single factor test. Validation test was conducted. RESULTS： The optimal extraction technology of Chaihu anxin capsules was adding 11 times of water， soaking for 10 h， extracting for 2 times， refluxing for 1.5 h each time. In validation test， the relative deviation of comprehensive scoring value to predicted value was 1.87％ for 3 batches of samples （RSD＜2％， n＝3）. CONCLUSIONS： The optimal extraction technology is simple， stable and suitable for further production of Chaihu anxin capsules.
