Analysis of Drug Use and Pharmaceutical Care of a Child with Congenital Heart Disease and Infective Endocarditis
- VernacularTitle:1例先天性心脏病合并感染性心内膜炎患儿的用药分析和药学监护
- Author:
Chun HUANG
1
;
Taotao LIU
1
;
Xia JIANG
1
;
Shuangyi TANG
1
;
Yue QIU
1
Author Information
1. Dept. of Pharmacy，the First Affiliated Hospital of Guangxi Medical University，Nanning 530021，China
- Publication Type:Journal Article
- Keywords:
Children;
Congenital heart;
Infective endocarditis;
Vancomycin;
Pharmaceutical care
- From:
China Pharmacy
2019;30(7):996-995
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To provide reference for optimizing the treatment of children with infective endocarditis. METHODS： Clinical pharmacists provide whole process pharmaceutical care for a child with congenital heart disease and infective endocarditis admitted to our hospital in April 2017. According to the individual situation of child， when therapy efficacy was poor， medication suggestions were put forward by timely referring to the guide and literature as well as combined with pharmacists’ work experience. RESULTS： After treatment with vancomycin at normal dose of 38 mg/（kg·d）， the vancomycin blood concentration （1.3 μg/mL） was low， and the treatment effect was poor. Clinical pharmacist made two suggestions to adjust the dose of vancomycin. The first dose was 45 mg/（kg·d）， the second dose was 60 mg/（kg·d）； pediatrician adopt clinical pharmacist recommendations completely. After treatment， the child’s body temperature was normal； vancomycin blood trough concentration increased to 5.8-6.5 μg/mL， and the disease was controlled. CONCLUSIONS： During vancomycin treatment of infective endocarditis in children， clinical pharmacists should provide pharmaceutical care throughout the course and pay close attention to the blood trough concentration of vancomycin in order to ensure the rational use of drugs in children.
