Optimization of the Hot Sand Processing Technology for Alpinia officinarum by Central Composite Design-response Surface Method
- VernacularTitle:星点设计-响应面法优选高良姜的砂烫炮制工艺
- Author:
Xianmei DENG
1
;
Simin HUANG
1
;
Yuling CHEN
1
;
Jiang MENG
2
;
Bin ZHAO
3
Author Information
1. Dept. of Pharmacy，Zhaoqing Medical College，Guangdong Zhaoqing 526000，China
2. School of TCM，Guangdong Pharmaceutical University，Guangzhou 510006，China
3. Dept. of Pharmacology，Zhongshan Torch Polytechnic，Guangdong Zhongshan 528436，China
- Publication Type:Journal Article
- Keywords:
Alpinia officinarum;
Processed Alpinia officinarum;
Hot sand processing;
Central composite design-response surface method;
Galangin;
Curcumin
- From:
China Pharmacy
2019;30(7):931-936
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To optimize the hot sand processing technology of Alpinia officinarum，and to provide scientific evidence for the standardized processing of A. officinarum. METHODS：The contents of galangin and curcumin in processed A. officinarum were determined by HPLC. Based on single factor test，using processing temperature and processing time as factors，comprehensive score of galangin and curcumin contents as index，central composite design-response surface method was used to optimize hot sand processing technology of A. officinarum，and the processing technology was validated. RESULTS：The optimal processing technology included processing temperature of 200 ℃ and processing time of 5.5 min. In validation tests，average comprehensive score was 94.38 （RSD＝1.02％），relative deviation of which to predicted value 93.74 was 0.68％. CONCLUSIONS：The optimized processing technology is simple and predictable. It can be used for hot sand processing technology of A. officinarum.
