Therapeutic Efficacy of Reteplase versus Alteplase in the Treatment of Acute Myocardial Infarction in China ：A Meta-analysis
- VernacularTitle:瑞替普酶对比阿替普酶治疗中国急性心肌梗死患者疗效的Meta分析
- Author:
Xuan XIONG
1
,
2
;
Dongke YU
1
,
2
;
Yuan ZHANG
1
,
2
;
Yuan BIAN
1
,
2
;
Qinan YIN
1
,
2
;
Yao CHEN
1
,
2
;
Rongsheng TONG
1
Author Information
1. Dept. of Pharmacy，Sichuan Academy of Medical Sciences/Sichuan Provincial People’s Hospital，Chengdu 610072，China
2. Personalized Drug Therapy Key Laboratory of Sichuan Province，School of Medicine，University of Electronic Sc ience and Technology of China，Chengdu 610072，China
- Publication Type:Journal Article
- Keywords:
Alteplase;
Reteplase;
Acute myocardial infarction;
Chinese;
Meta-analysis
- From:
China Pharmacy
2019;30(9):1279-1284
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To evaluate therapeutic efficacy of reteplase versus alteplase in the treatment of acute myocardial infarction in China， and to provide evidence-based reference for clinical treatment. METHODS： Retrieved from Cochrane library， PubMed， Embase， Medline， CJFD， CSJD， Wanfang database by computor， etc.， also by manual search， RCTs about therapeutic efficacy （recanalization rate of thrombolysis） of reteplase （trial group） versus alteplase （control group） in the treatment of acute myocardial infarction in China were collected from Jan. 1995 to Sept. 2018. After data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0， Meta-analysis was performed for recanalization rate of thrombolysis by using Rev Man 5.3 software. RESULTS： A total of 23 RCTs were included， involving 1 742 patients. Results of Meta-analysis showed that recanalization rate of thrombolysis in trial group was significantly higher than control group， with statistical significance [OR＝0.61，95％CI（0.50，0.73），P＜0.001]. Sub-group Meta-analysis was performed according to the successful time of thrombolysis. Results of Meta-analysis showed that recanalization rate of thrombolysis in trial group 1 h [OR＝0.38，95％CI（0.25，0.58），P＜0.001]， 1.5 h [OR＝0.44，95％CI（0.25，0.79），P＝0.006] and 2 h [OR＝0.62，95％CI（0.42，0.92），P＝0.02] after thrombolysis were significantly higher than control group， with statistical significance. CONCLUSIONS： The recanalization rate of thrombolysis by reteplase in Chinese patients with acute myocardial infarction in better than by alteplase.
