Study on Anti-inflammatory Mechanism of Couplet Medicine of Notopterygium incisum -Angelica pubescens Based on Network Pharmacology
- VernacularTitle:基于网络药理学的羌活-独活药对抗炎作用机制研究
- Author:
Kaixuan DUAN
1
;
Yuewen LI
1
;
Hebo LIU
2
;
Bolong WANG
1
Author Information
1. School of Chemical and Biological Engineering，Yichun University，Jiangxi Yichu n 336000，China
2. School of Medicine，Yichun University，Jiangxi Yichun 336000，China
- Publication Type:Journal Article
- Keywords:
Notopterygium incisum;
Angelica pubescens;
Couplet medicine;
Anti-inflammatory mechanism;
Target protein interaction;
Signaling pathway
- From:
China Pharmacy
2019;30(9):1241-1246
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To predict the anti-inflammatory active components and mechanism of couplet medicine of Notopterygium incisum-Angelica pubescens. METHODS： According to the principle of oral bioavailability≥30％ and drug- likeness≥0.18， active components of N. incisum and A. pubescens were screened； TCMSP was used to predict and screen the potential target of them. Using “Anti-inflammatory” as keyword， inflammatory related target genes were retrieved from human gene database Genecards. Common target was screened by mapping the target genes of active ingredients from couplet medicine of N. incisum-A. pubescens. The active ingredient-target network was established by using Cytoscape 3.5.1 software. The screened targets were used to construct the target protein interaction （PPI） network on the STRING V 10.5 platform. Its anti-inflammatory mechanism was studied by KEGG signaling pathway and GO biological enrichment analysis. RESULTS： Totally 15 active components such as coumarin， beta-sitosterol， ammidin， nodakenin were selected from couplet medicine of N. incisum-A. pubescens. Acting on 49 targets such as transcription factor AP-1， PI3-kinase subunit gamma， estrogen receptor， they mainly involved 19 signaling pathways such as hepatitis B and cell apoptosis， and were involved in 47 biological processes such as regulating inflammatory response and prostaglandin biosynthesis. CONCLUSIONS： The anti-inflammatory mechanism of active components of couplet medicine of N. incisum-A. pubescens on multi-target， multi-channel and multi-biological processes is predicted， and it points out the direction for further anti-inflammatory mechanism study.
