Study on Network Pharmacology of the Mechanism of Lysimachia christinae in the Treatment of Cholecyst Related Disease
- VernacularTitle:金钱草治疗胆囊相关疾病作用机制的网络药理学研究
- Author:
Peng HUANG
1
,
2
;
Jialin QU
1
;
Le CHANG
3
;
Hongwen KE
4
;
Ying YANG
1
,
2
;
Aijing LENG
2
Author Information
1. Clinical Laboratory of Integrative Medicine，the First Affiliated Hospital of Dalian Medical University，Liaoning Dalian 116011，China
2. Institute of Integrative Medicine，Dalian Medical University，Liaoning Dalian 116044，China
3. Jinzhou Institute for Drug Control，Liaoning Jinzhou 121000，China
4. Dept. of Pharmacy，the First Affiliated Hospital of Dalian Medical University，Liaoning Dalian 116011，China
- Publication Type:Journal Article
- Keywords:
Lysimachia christinae;
Cholecyst related diseases;
Target;
Pathway;
Network pharmacology;
Mechanism
- From:
China Pharmacy
2019;30(9):1220-1225
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To explore the mechanism of Lysimachia christinae in the treatment of cholecyst related diseases by network pharmacology. METHODS： The active ingredients of L. christinae were screened through TCMSP database with “Lipinski rule” and “Oral bioavailability ＞30％” rules， and their related targets were predicated correspondingly， then compound-target network were constructed by Cytoscape 3.2.1 software. Disease related targets were predicted by searching TTD database， OMIM database， PharmGKB database， DrugBank database and GAD database with “cholelithiasis” “gallstones” “cholecystitis” and “cholangitis” as keywords. Then， the network of disease-target was constructed and merged with active ingredient target to obtain therapeutic target. After pathway enrichment analysis of therapeutic target were performed by utilizing the DAVID database， molecular docking between target and active ingredient was also conducted in order to screen the main active ingredients of L. christinae. RESULTS： Twenty-seven active ingredients with good oral absorption and drug-like properties were screened from L. christinae. Thirty-three targets were attained after constructing and merging the network. Seven pathways， mainly related to cancer pathway and ABC transporter pathway were achieved. Top 4 active ingredients of L. christinae in the list of docking score were kaempferin， acacia， hesperetin and isorhamnetin， which acted on ABCC3， ABCB1， ABCC2， ABCB4 target. CONCLUSIONS： L. christinae treat cholecyst related diseases through ABC transporter pathway.
