Medication Therapy Management Practice of A Chronic Disease Patient with Adverse Drug Reactions Caused by Candesartan
- VernacularTitle:1例坎地沙坦致不良反应慢病患者实施药物治疗管理的实践
- Author:
Lili LIU
1
;
Yi FENG
2
;
Wensheng LIU
1
;
Yijun WANG
1
;
Chaoyi REN
1
;
Yuyu LUO
1
Author Information
1. Tianjin Third Central Hospital/ Tianjin Institute of Hepatobiliary Disease/Tianjin Key Lab of Artificial Cells/Research Center of Artificial Cell Engineering Technology，Ministry of Public Health，Tianjin 300170，China
2. Tianjin Fifth Central Hospital/ Peking University Binhai Hospital，Tianjin 300450，China
- Publication Type:Journal Article
- Keywords:
Naranjo assessment scale method;
Roussel Uclaf causality assessment method;
Medication management;
Candesartan;
ADR
- From:
China Pharmacy
2019;30(11):1559-1564
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To provide reference for the evaluation of the correlation between drugs and adverse drug reaction （ADR） and the implementation of medication therapy management （MTM）. METHODS： Clinical information of a elderly patient with chronic disease （hypertension and coronary heart disease） whose suffered from leukocyte and platelet counts reduction and abnormal liver biochemical examination after taking candesartan were analyzed retrospectively in outpatient department of Tianjin Third Central Hospital. MTM pharmacists analyzed the correlation of candesartan with ADR using Naranjo evaluation scale method. The reasons for abnormal liver biochemical examination were analyzed by Naranjo evaluation scale method combined with Roussel Uclaf causality analysis method （called RUCAM method for short）. The medication reconciliation was conducted according to the results， and pharmacists cooperated with doctors to set individualized medication regimen and follow-up. RESULTS： By Naranjo evaluation scale method， analysis results showed that candesartan was “probably related” to ADR. By RUCAM method， analysis results showed that candesartan was “probably related” to liver biochemical abnormalities. MTM pharmacists suggested that candesartan should be stopped in time and the patient’s medication should be adjusted. The physician and the patient adopted the pharmacist’s advice. After 38 days of drug withdrawal， the patient’s ADR symptoms disappeared， and leukocyte count， platelet count and liver biochemical examination were normal. After adjustment of medication， the patient was followed up for 6 months with normal blood pressure. CONCLUSIONS： Naranjo evaluation scale method and RUCAM are simple and feasible in evaluating the correlation of drugs with ADR and hepatotoxicity. The two methods are consistent in evaluating the correlation between drugs and hepatotoxicity. Naranjo scale method and RUCAM method can be combined to analyze the correlation between drugs and ADR with abnormal liver biochemical examination.
