Study on Molecular Mechanism of Xiaochaihu Decoction for Sepsis Based on TCMIP Platform
- VernacularTitle:基于中药整合药理学计算平台的小柴胡汤抗脓毒症的分子机制研究
- Author:
Qingxin YANG
1
,
2
;
Hongjun LYU
1
;
Xiaobo WANG
1
;
Jinsong REN
2
;
Nan ZENG
1
Author Information
1. Teaching and Research Section of Pharmacology，College of Pharmacy，Chengdu University of TCM，Chengdu 611137，China
2. School of Pharmacy，Sichuan College of TCM，Sichuan Mianyang 621000，China
- Publication Type:Journal Article
- Keywords:
Xiaochaihu decoction;
TCMIP;
Sepsis;
Mechanism of action;
Chemical ingredients;
Target;
Pathway analysis
- From:
China Pharmacy
2019;30(11):1506-1512
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To investigate the substance basis and mechanism of Xiaochaihu decoction in treatment of sepsis， and to provide reference for clinical application and R&D of the decoction. METHODS： Based on TCM integrative pharmacology platform （TCMIP）， chemical component analysis of Xiaochaihu decoction， disease target prediction， gene function and pathway enrichment analysis were all performed. The multi-dimensional network relationship of “TCM-chemical components-core targets-key pathways” was established， and the mechanism of Xiaochaihu decoction in treatment of sepsis was investigated. RESULTS： A total of 224 predicted chemical ingredients of Xiaochaihu decoction （including saikoside， ginsenoside， glycyrrhizin， etc.） interacted with 118 key targets about sepsis， including PF4， MYD88， TLR4， CD14， NOS3， etc. Its anti-sepsis mechanism involved nervous system， endocrine system， immune response and energy metabolism， etc. CONCLUSIONS： Based on “neuronal- endocrine-immune-metabolism”， Xiaochaihu decoction achieved its role in regulating sepsis by multi-level， multi-channel and multi-channel. This research may reveal the potential mechanism of Xiaochaihu decoction for sepsis， and the prescription provide theoretical basis for further experimental research of pharmacodynamic substance basis and mechanism of action．
