Primary testicular diffuse large B-cell lymphoma: A clinicopathological analysis.
- Author:
Xiao FENG
1
;
Xiao-Die ZHOU
1
;
Xiao-Xia WANG
1
;
Xuan WANG
1
;
Sheng-Bing YE
1
;
Zhen-Feng LU
1
;
Qiu RAO
1
;
Wei BAO
1
;
Qun-Li SHI
1
Author Information
1. Department of Pathology, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- Keywords:
diffuse large B-cell lymphoma, primary;
pathological diagnosis;
testis
- From:
National Journal of Andrology
2019;25(2):139-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features, immunophenotype and treatment of primary testicular diffuse large B-cell lymphoma (DLBCL).
METHODS:We retrospectively analyzed the pathomorphological characteristics and immunohistochemical markers of 23 cases of primary testicular DLBCL as well as their clinicopathological features with a review of the relevant literature. The patients were aged 48－76 (mean 61.4) years, 82.6% over 50 years, and all clinically presented with painless progressive unilateral testicular swelling, 9 cases in the left and the other 14 in the right testis.
RESULTS:Histologically, the lymphomas were composed of large atypical cells with prominent karyokinesis and diffusely infiltrated the testicular parenchyma. The neoplastic cells were positive for B-cell markers. Five of the patients were followed up for 2 to 32 months, of whom 4 survived and 1 died at 9 months.
CONCLUSIONS:Primary testicular DLBCL is a rare tumor with an invasive biological behavior, mostly found in elderly males and easily misdiagnosed or missed in diagnosis. Histopathology plays a key role and immunohistochemical markers are of high value in the definite diagnosis and differential diagnosis of the tumor.
