Effect of Yishen Zhuangyang Cream on penile hemodynamics in ED patients.
- Author:
Cun-Chao HUANG
1
Author Information
1. Department of Andrology, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530011, China .
- Publication Type:Journal Article
- Keywords:
Yishen Zhuangyang Cream;
clinical effect;
penile hemodynamics;
erectile dysfunction
- From:National Journal of Andrology
2019;25(2):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Yishen Zhuangyang Cream (YZC) on the hemodynamic parameters of the penile cavernous artery in ED patients and explore its pharmacological mechanisms.
METHODS:Ninety-two outpatients with ED were randomly assigned to receive YZC (n = 60) or placebo ( the control group, n = 32), all for 4 weeks. Comparisons were made between the two groups of patients in the IIEF-5 scores, penile erectile hardness (PEH) scores and the hemodynamic parameters of the penile cavernous artery before and after treatment.
RESULTS:The IIEF-5 and PEH scores were both significantly increased in the YZC group after treatment in comparison with the baseline (19.18 ± 3.56 vs 12.63 ± 3.78, P < 0.01; 3.58 ± 0.50 vs 3.21 ± 0.62, P < 0.01), and higher than in the control group after medication (19.18 ± 3.56 vs 13.72 ± 2.85, P = 0.01; 3.58 ± 0.50 vs 3.28 ± 0.58, P < 0.01), but no statistically significances were observed between the two groups after treatment or within each group before and after medication in the peak systolic velocity (PSV), end-diastolic velocity (EDV), or resistance index (RI) of the penile artery (P > 0.05). The rate of therapeutic effectiveness was remarkably higher in the YZC than in the control group (73.33% vs 21.88%, Z = －4.665, P < 0.01).
CONCLUSIONS:YZC can improve the erectile function of ED patients by increasing IIEF-5 and PEH scores but has no significant effect on penile hemodynamics. The pharmacological mechanisms of YZC acting on ED need to be further studied.
