Roles of cyclins in the progression of spermatogenesis.
- Author:
Bin CAI
1
;
Da-Lin SUN
1
;
Wei-Min DENG
1
;
Bao-Fang JIN
1
Author Information
1. Department of Integrated Chinese and Western Medicine for Andrology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China.
- Publication Type:Journal Article
- Keywords:
cyclin-dependent kinase;
spermatogenesis;
cyclin
- From:National Journal of Andrology
2019;25(2):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Spermatogenesis is a complex and precise process of differentiation of germ cells, which involves three stages: mitosis of spermatogonia, meiosis of spermatocytes and formation of spermatozoa. The process is controlled by many factors, including regulation of cyclins in spermatogenic cells, which plays a pivotal role. Cyclins form heterologous dimer compounds with protein kinase activity by binding to cyclin-dependent kinases, then phosphorylate multiple proteins and promote the orderly conduct of each phase of the cell cycle. In recent years, cyclins A, B, D and E have been found to play important roles in the regulation of spermatogenesis. This article presents an overview on the roles of these four cyclins in regulating the progression of spermatogenesis.
