Association between Sugar-Sweetened Beverage Consumption and the Risk of Gout: A Meta-Analysis.
10.4078/jrd.2016.23.5.304
- Author:
Young Ho LEE
1
;
Gwan Gyu SONG
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. lyhcgh@korea.ac.kr
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Sugar-sweetened beverages;
Gout;
Risk
- MeSH:
Beverages*;
Female;
Gout*;
Humans;
Male
- From:Journal of Rheumatic Diseases
2016;23(5):304-310
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The aim of this study was to analyze published data for an association between consumption of sugar sweetened beverages (SSBs) and the development of gout. METHODS: We performed a meta-analysis to examine the highest and lowest categories of SSB consumption in relation to risk of gout. RESULTS: Three studies including 2,606 gout patients among 134,008 participants were included. Meta-analysis revealed a significant association between SSB consumption and gout risk (relative risk [RR]=1.986, 95% confidence interval [CI]=1.447~2.725, p=2.2×10⁻⁵). Stratification by ethnicity showed a significant association between SSB consumption and gout risk in ethnic Europeans, but not in Polynesians (RR=2.110, 95% CI=1.470~ 2.725, p=5.1×10⁻⁵; RR=1.624, 95% CI=0.842~3.135, p=0.148, respectively). SSB consumption and gout risk were associated in original data and imputed data, for both men and women, regardless of data type and sex. The association between the highest SSB consumption group and gout was stronger than the association between the middle group and gout, indicating a dose-response gradient (RR=1.986, 95% CI=1.447~2.725, p<2.2×10⁻⁵ vs. RR=1.260, 95% CI=1.043~1.522, p<0.016). CONCLUSION: This meta-analysis of 134,008 participants demonstrates that SSB consumption is associated with an elevated risk of gout development, particularly in the ethnic European population. Available evidence indicates a dose-response gradient of the relationship between SSB consumption and gout risk.
