Relationship of small non-coding RNA in the seminal plasma with male infertility: An update.
- Author:
Yu-Ying BIAN
1
;
Cheng WANG
2
;
Chun-Ni ZHANG
2
Author Information
1. Medical College of Jiangsu University, Zhenjiang, Jiangsu 212013, China.
2. Department of Clinical Laboratory, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- Keywords:
exosome;
miRNA;
piRNA;
seminal plasma;
small non-coding RNA;
male infertility
- From:National Journal of Andrology
2019;25(5):460-465
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of male infertility is increasing year by year, but there is a lack of non-invasive accurate diagnostic indicators for this disease, and the pathogenesis of idiopathic infertility is not yet fully clarified. Recent studies have found that there are various small non-coding RNAs (sncRNA) in the human seminal plasma and spermatic exosomes, which can be used as a novel non-invasive biomarker of male infertility. This review outlines the latest research updates on the relationship between sncRNAs in the seminal plasma and male infertility, aiming to provide some new ideas for the screening of the molecular markers of male infertility and study of its underlying molecular mechanisms.
