Intraflagellar transport is essential for spermiogenesis.
- Author:
Zhi-Bing ZHANG
1
;
Heng-Qi WANG
1
;
Ling ZHANG
1
Author Information
1. School of Public Health, Wuhan University of Science and Technology, Hubei Province Key Laboratory for Occupational Hazard Identification and Control, Wuhan, Hubei 430065, China.
- Publication Type:Journal Article
- Keywords:
ciliogenesis;
male fertility;
spermiogenesis;
intraflagellar transport
- From:National Journal of Andrology
2019;25(3):195-201
- CountryChina
- Language:Chinese
-
Abstract:
Intra flagellar transport (IFT) is an evolutionarily conserved mechanism thought to be essential for the assembly and maintenance of most eukaryotic cilia and flagella. Development of the sperm tail axoneme resembles the cilia formation, which is organized by intraflagellar transport (IFT). Of all mammalian cells, sperm have the longest motile cilia, but few studies are reported on the role of IFT in the formation of sperm flagella and the mechanisms of IFT in spermiogenesis. This article focuses on the role of IFT in spermatogenesis and the importance of IFT in male fertility.