Follicular Variant of Papillary Thyroid Carcinoma: Clinicopathological Features According to Histologic Subgroup.
10.16956/kjes.2011.11.4.256
- Author:
Yea Jeong KIM
1
;
Chi Won SUNG
;
Young Sam PARK
;
Cheol Seung KIM
;
Eun Hye CHOI
;
Myoung Jin JOO
Author Information
1. Department of Surgery, Presbyterian Medical Center, Jeonju, Korea. Saint071@hanmail.net
- Publication Type:Original Article
- Keywords:
Thyroid papillary carcinoma;
Follicular variant;
Clinicopathologic features;
Encapsulated type;
Infiltrative type
- MeSH:
Biopsy;
Diagnosis;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Recurrence;
Thyroid Gland*;
Thyroid Neoplasms*
- From:Korean Journal of Endocrine Surgery
2011;11(4):256-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The follicular variant of papillary thyroid carcinoma (FVPTC) is difficult to diagnose due to pathologic features. There is also debate on the optimal extent of surgery. We separated FVPTC into two groups and compared the clinical features in an attempt to apply the treatment. METHODS: All 40 patients with FVPTC who were diagnosed between 1990 and 2009 were reviewed and separated into two groups, an encapsulated group and an infiltrative group, based on whether a capsule was formed or infiltration occurred. These two different subtypes of FVPTC were compared on the traits of sensitivity of diagnosis and clinicopathologic features. RESULTS: After review by a pathologist, 21 of 40 patients (55%) were found to have encapsulated tumors, and 18 patients (45%) had infiltrative tumors. There was no difference in age, sex, or size. Patients with encapsulated FVPTC had a significantly lower rate of lymph node metastasis (4.5%), multicentric tumors (18.2%), and thyroid capsular invasion (9.1%) compared with the infiltrative tumor group (50%, 50% and 50%, P<0.05). There was no difference in FNA sensitivity between the two groups, but the sensitivity to frozen biopsy was higher in the infiltrative group. There was no recurrence in the encapsulated group, but 4 patients (22.2%) experienced recurrence in the infiltrative group. CONCLUSION: FVPTC can be separated into two subgroups by histologic features, and there are some clinicopathologic differences between the two groups. Patients who had encapsulated FVPTC had a lower rate of lymph node metastasis, multicentric tumors, and thyroid capsular invasion. They also showed a lower rate of recurrence than the infiltrative group. It is suggested that the encapsulated group can be treated with limited surgery and the infiltrative group needs aggressive treatment.
