Correlation of urine phthalate metabolite levels with blood pressure in first-grade children
10.16835/j.cnki.1000-9817.2019.09.021
- VernacularTitle:短链邻苯二甲酸酯暴露和儿童血压的关联性研究
- Author:
YAO Yao, WU Yu, CHEN Dingyan, ZHOU Li, CHENG Jinquan, YUAN Guanxiang, WEN Ying, YIN Jiangwei, LI Honghua
1
Author Information
1. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan(430030), China
- Publication Type:Journal Article
- Keywords:
Blood pressure;
Regression analysis;
Child
- From:
Chinese Journal of School Health
2019;40(9):1356-1359
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between blood pressure and urinary phthalandione, MMP, MEP, MnBP, MiBP, PAEs.
Methods:Three schools were selected from Shenzhen, China for the present study. A total of 765 firstgrade students of Han ethnicity were recruited voluntarily from the selected schools during September 2016 to June 2017. They were divided into normal blood pressure (BP) group (lower than P90 group) and high BP group (BP≥P90). Linear and Logistic regression models were used to analyze the relationships between blood pressure and urine phthalate metabolite levels.
Results:Urinary MMP and MnBP in students of high BP group were significantly higher than that of students in normal BP group(t=13.12, 3.97, P<0.05). Linear regression models showed that Z score increased when MMP and MnBP levels increased(P<0.05). Logistic regression model suggested that the risk of high BP increased with the increment of MMP level adjusting creatinine, sex, age and BMI(OR=1.47, P<0.05). There was no statistical significance in the differences after adjusting many factors including family income and education level of parents(P>0.05).
Conclusion:Urinary phthalate metabolite levels are positively associated with blood pressure in first-grade children.
