Roles of IL1R2 in tumorigenesis
10.3872/j.issn.1007-385x.2018.08.012
- VernacularTitle:IL1R2在肿瘤发生发展中的作用
- Author:
LIU Yinting
1
;
LU Binfeng
2
;
JIANG Jinting
3
Author Information
1. 1. Tumor Biological diagnosis and treatment Center of the third affiliated Hospital of Suzhou University Cell Therapy Research Institute of Jiangsu tumor Immunotherapy Engineering Technology Research Center
2. 2. Deparment of Immunology, University of Pittsburgh, USA
3. Tumor Biological diagnosis and treatment Center of the third affiliated Hospital of Suzhou University Cell Therapy Research Institute of Jiangsu tumor Immunotherapy Engineering Technology Research Center
- Publication Type:Review
- Keywords:
IL1R2;
诱捕受体;
肿瘤;
生物靶标
- From:
Chinese Journal of Cancer Biotherapy
2018;25(8):822-829
- CountryChina
- Language:Chinese
-
Abstract:
IL-1有IL-1α和IL-1β两种亚型，其受体家族包括I型和II型两种受体形式（IL1R1和IL1R2）以及一种受体辅助蛋白 （IL1RAP）。在IL1RAP帮助下，IL-1α和IL-1β均可与ILR1形成IL-1/IL1R1/IL1RAP复合物，激活下游信号转导通路，发挥生物学 作用； IL1R2由于缺少胞内TIR结构域无法介导IL-1信号通路，而能通过与IL1R1竞争性结合抑制IL-1的作用。IL1R2起初被认 为是一种IL-1的诱捕受体，但在后续的研究中发现其在多种肿瘤中有异常表达，且多数呈现异常上调状态，仅在少数肿瘤中低表 达，其表达与许多肿瘤的发生发展以及预后有着重要关联。本文针对IL1R2在肿瘤发生发展中的作用方面的相关研究进展进行 综述。
- Full text:20180812.pdf
