Preparation and Quality Evaluation of Pogostone Transfersomes
- VernacularTitle:广藿香酮传递体的制备及质量评价
- Author:
Lina MA
1
,
2
;
Zhimin WU
1
,
2
;
Chang YANG
1
;
Shujuan GUO
1
;
Liping CHEN
1
;
Yanjiang QIAO
1
,
2
;
Xinyuan SHI
1
Author Information
1. School of Chinese Materia Medica，Beijing University of TCM，Beijing 102488，China
2. Dept. of TCM Information，School of TCM，Beijing University of TCM，Beijing 102488，China
- Publication Type:Journal Article
- Keywords:
Pogostone;
Transfersome;
Film dispersion method;
Preparation;
Entrapment efficiency;
Quality evaluation;
Accumulative penetration volume
- From:
China Pharmacy
2019;30(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To prepare pogostone transfersomes， and to evaluate its quality. METHODS： Film dispersion method was used to prepare pogostone transfersomes. Using the accumulative penetration volume （Qn） and accumulative penetration ratio （PR） of pogostone as evaluation indexes， the types of surfactant， formulation were screened in respects of the dosage of surfactant and the dosage of pogostone. The pogostone transfersomes were prepared with optimal formulation； the morphology， particle size distribution and Zeta potential were observed and the entrapment efficiency was measured. RESULTS： The optimal formulation was as follows as the sodium cholate was selected as surfactant； the dosage of sodium cholate was 0.25 g； the dosage of pogostone was 15 mg. The optimal pogostone transfersomes were ivory-white suspension； average particle size was （115.6±3.65） nm （RSD＝3.20％，n＝3）； PDI was 0.185±0.008 （RSD＝4.30％， n＝3）； Zeta potential was （－13.76±0.225） mV （RSD＝1.70％，n＝3）； entrapment efficiency of pogostone was （46.01±0.40）％ （RSD＝0.87％，n＝3）； Qn was （378.76±0.61） μg/cm2 （RSD＝0.20％，n＝3）； PR was （89.02±0.96）％ （RSD＝1.10％，n＝3）. CONCLUSIONS： Prepared pogostone transfersomes are in line with quality requirements， which can provide reference for the further study of new dosage form of pogostone.
