Practice and Exploration of the Construction of Management System for Off-label Drug Use in Our Hospital
- VernacularTitle:我院超说明书用药管理体系构建的实践与探索
- Author:
Liang HUANG
1
,
2
;
Lingli ZHANG
1
,
2
;
Linan ZENG
1
,
2
;
Yunzhu LIN
1
,
2
;
Chuan ZHANG
1
,
2
;
Min CHEN
1
,
2
;
Dan LIU
1
Author Information
1. Dept. of Pharmacy/Evidence-Based Pharmacy Center，West China Second University Hospital，Sichuan University，Chengdu 610041，China
2. Key Lab of Birth Defects and Related Diseases of Women and Children （Sichuan University ），Ministry of Education，Chengdu 610041，China
- Publication Type:Journal Article
- Keywords:
Medical institutions;
Pharmaceutical administration;
Off-label drug use;
Record management;
Evidence quality
- From:
China Pharmacy
2019;30(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To establish the management system for off-label drug use in a medical institutions， and to standardize the behaviors of off-label drug use and improve the rational drug use. METHODS： Based on evidence-based researches for off-label drug use， management system of off-label drug use was established in our hospital， and off-label drug use management was carried out. The effects of management system were evaluated with the number of records for off-label drug use and pass rate of approval as indexes. RESULTS： Since the year of 2011， the management system for off-label drug use had gradually established and improved in our hospital； the mode of registration and approval for off-label drug use was established by based on a multi-disciplinary team management and quality classification for clinical evidence. Up to 2016， a total of 252 records for off-label use were submitted， among which 159 （accounting for 59.77％） were for pediatrics and 93 （accounting for 34.96％） were for gynecology and obstetrics. Among the submitted records， 181 had passed the examination and approval， and the pass rate was 64.29％. Special prescription comments indicated that the numbers of off-label use medical orders in inpatient medical orders showed a downward trend， and the proportion of recorded medical orders of off-label use had increased from 17.33％ in 2013 to 84.00％ in 2016. CONCLUSIONS： The management system for off-label drug use in medical institutions can effectively improve the clinical understanding of off-label drug use， standardize the behavior of off-label drug use.
