Meta-analysis of the Effectiveness of Trolamine for Preventing and Treating Radiation Dermatitis and Quality Evaluation of GRADE Evidence
- VernacularTitle:三乙醇胺防治放射性皮炎有效性的Meta分析及GRADE证据质量评价
- Author:
Xiaoqing LONG
1
;
Jisheng WANG
2
;
Lin JIA
1
;
Jing CHEN
2
;
Mingming CHU
3
;
Jianjun HAN
1
;
Xia HE
1
;
Lisha CAO
2
;
Dehua ZHAO
1
Author Information
1. Dept. of Oncology，Mianyang Third People’s Hospital/Sichuan Mental Health Center，Sichuan Mianyang 621000，China
2. Dept. of Clinical Pharmacy，Mianyang Third People’s Hospital/Sichuan Mental Health Center，Sichuan Mianyang 621000，China
3. Dept. of Clinical Pharmacy，the Second Affiliated Hospital of Army M edical University，Chongqing 400037，China
- Publication Type:Journal Article
- Keywords:
Trolamine;
Radiation dermatitis;
Preventing and treating;
Effectiveness;
Meta-analysis;
GRADE evidence quality evaluation
- From:
China Pharmacy
2019;30(2):258-263
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To evaluate the effectiveness of trolamine for preventing and treating radiation dermatitis （RD） and evidence quality， and to provide reference for clinical use. METHODS： Retrieved from PubMed， Cochrane library， Embase， CNKI， Wanfang and VIP database， randomized controlled trials （RCTs） about trolamine （trial group） versus usual care （control group） for preventing and treating RD were collected. After data extraction， Cochrane bias risk assessment tool 5.0.2 was used to assess the bias risk， and Rev Man 5.3 statistical software was used to perform the Meta-analysis. GRADE evidence quality grading system was used to evaluate the evidence quality of outcome indexes. RESULTS： Seven RCTs were included， involving 782 patients. Results of Meta-analysis showed that there was no statistical significance in total incidence of RD [OR＝0.50， 95％CI （0.23， 1.11）， P＝0.09]， and the incidence of grade Ⅰ RD [OR＝1.32， 95％CI（0.96，1.81）， P＝0.09]， grade Ⅱ RD [OR＝1.07， 95％CI（0.80，1.42）， P＝0.66]， grade Ⅲ RD [OR＝0.69， 95％CI（0.45，1.04）， P＝0.07] or grade Ⅳ RD [OR＝0.43， 95％CI（0.17，1.05）， P＝0.07] between 2 groups. Results of Grade evidence quality evaluation showed that total incidence of RD， and the incidence of grade Ⅱ RD and grade Ⅳ RD were recommended by moderate-level evidence in 2 groups， while the incidence of grade Ⅰ and grade Ⅲ RD were recommended by low-level evidence. CONCLUSIONS： Trolamine is not effective in preventing and treating RD， and can not reduce the incidence of RD.
