Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease

Author: Chang Myung OH ¹ ; Dongryeol RYU ; Sungsoo CHO ; Yangsoo JANG
Author Information

1. Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
Publication Type:Review
Keywords: Mitochondrial quality control; Heart; Urolithin A; Spermidine
MeSH: Adenosine Triphosphate; Cardiovascular Diseases; Cause of Death; Heart Failure; Heart; Homeostasis; Mitochondria; Mitochondrial Degradation; Organelles; Quality Control; Spermidine; Unfolded Protein Response
From:Korean Circulation Journal 2020;50(5):395-405
CountryRepublic of Korea
Language:English
Abstract: Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondrial dysfunction is the root cause for developing heart failure. Therefore, maintenance of mitochondrial quality control (MQC) is an essential process for cardiovascular homeostasis and cardiac health. In this review, we describe the major mechanisms of MQC system, such as mitochondrial unfolded protein response and mitophagy. Moreover, we describe the results of MQC failure in cardiac mitochondria. Furthermore, we discuss the prospects of 2 drug candidates, urolithin A and spermidine, for restoring mitochondrial homeostasis to treat CVD.