Expression of miR-622 and its significance in epithelial ovarian cancer
- Author:
Zhong-jun LI
1
;
Li-shan HUANG
1
;
Li-juan XIAO
1
;
Su-ran HUANG
1
;
Zhi-yong HOU
1
Author Information
- Publication Type:Journal Article
- Keywords: microRNA-622; ovarian cancer; invasion; migration
- From: Chinese Journal of Practical Gynecology and Obstetrics 2019;35(01):114-116
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the expression of microRNA-622(miR-622)in epithelial ovarian cancer,andanalyze its influence on tumor cell migration and invasion.METHODS:Epithelial ovarian cancer(n=125),benignepithelial ovarian tumors(n=45),and normal ovarian tissues(n=25)were obtained from January 2003 to December 2016 at Dongguan People's Hospital of Southern Medical University.The expression of miR-622 was determined by real-timePCR.The miR-622 mimics were transiently transfected into human ovarian cancer cells,and their influence on cellmigration and invasion was analyzed by Transwell assay.RESULTS:Higher miR-622 expression was found in epithelialovarian cancer tissues than in benign epithelial ovarian tumors and normal ovarian tissues(P<0.05).Expression of miR-622 was correlated with FIGO stage and lymphatic metastasis(P<0.05).Up-regulation of miR-622 promoted theinvasion and migration of SKOV3 cells in vitro.CONCLUSION:The expression level of miR-622 is increased in tumourtissues,which indicates that miR-622 might be involved in the progression of epithelial ovarian cancer by promotingcancer cell migration and invasion.
