Clinical value of HE4,CA125 and ROMA in diagnosis of ovarian epithelial malignant tumor
- Author:
Lin LIN
1
;
Mingxiu JU
;
Zhi-wei QIAO
;
Rui TONG
;
Chun-yan WANG
Author Information
- Publication Type:Journal Article
- Keywords: HE4; CA125; ROMA; ovarian epithelial tumor
- From: Chinese Journal of Practical Gynecology and Obstetrics 2019;35(12):1384-1387
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the value of HE4,CA125 and ovarian malignant tumor risk prediction models(ROMA)in the diagnosis of ovarian epithelial malignant tumors.METHODS: The clinical and pathological data of 247 patients with ovarian tumors(EOC 139 cases,BOT 18 cases,and benign ovarian tumor 90 cases)and 39 patients with uterine fibroids in Liaoning Tumor Hospital from September 2016 to August 2017 were retrospectively analyzed. The levels of serum CA125 and HE4 were measured before operation. The ROMA values were calculated and the relationship between CA125,HE4,ROMA values and clinical pathological parameters were analyzed. The diagnostic evaluation index was calculated,the receiver operating characteristic(ROC)curve was drawn,and the AUC value was also calculated.RESULTS: The positive rate of HE4 in the ovarian epithelial malignant tumor group was significantly higher than that in other groups before and after menopause,the difference being statistically significant(P<0.05).The positive rate of CA125 in the group of malignant epithelial tumor of ovary was significantly higher than that in other groups after menopause,the difference being statistically significant(P<0.05),but there was no statistical difference before menopause(P>0.05).There was no significant statistical difference in the positive rate of ROMA before or after menopause(P>0.05).The sensitivity of CA125 was higher than that of HE4 and ROMA. Specificity of HE4 was higher than that of CA125 and ROMA.Correct diagnosis index of ROMA was higher than that of HE4 and CA125.CONCLUSION: For the diagnosis of ovarian malignant epithelial tumors,the combined detection of serum HE4 and CA125 and ROMA model is superior to the individual detection of HE4 and CA125.
