Clinical study on the short-term outcome of asymptomatic bacterial vaginosis
- Author:
Rui ZHANG
1
;
Wen-xiang WU
1
;
Yi-qing WU
;
Li GUO
;
Ping LIU
;
Hui-hui BAI
1
;
Jia-hui-zi GAO
1
;
Han-yu DONG
1
;
Zhao-hui LIU
Author Information
- Publication Type:Journal Article
- Keywords: asymptomatic bacterial vaginosis; probiotics; vaginal microbiota
- From: Chinese Journal of Practical Gynecology and Obstetrics 2019;35(08):915-918
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To explore the method of management of asymptomatic bacterial vaginosis,and to evaluate the effect of probiotics on asymptomatic bacterial vaginosis and analyze the benefit gained by those patients.METHODS: A multicenter,randomized,double-blind,controlled study was performed with probiotics in test group,and placebo in control group,from september 2013 to september 2016 in 4 hospitals.Forty five patients in test group were treated with vaginal capsule probiotics,and placebo was used in forty-five patients in control group.The follow-up in both groups lasted for 4 weeks.Cure rate,relapse rate and progression rate in both groups were analyzed to evaluate the effect and the benefits gained by patients.RESULTS: Ninty patients were recruited in the study,and seventy-nine patients finished the study and were followed up with complete information.Two weeks after the treatment,in FAS the cure rate in test group was significantly higher than that of the control(44.4% vs. 6.7%,P<0.01),while the progression rate was lower than that of the control(8.9% vs. 11.1%,P>0.05).In PPS,the cure rate in test group was significantly higher than that of the control(52.5% vs. 2.6%,P<0.01),while the progression rate was lower than that of the control(5.0% vs. 7.7%,P>0.05).After 2 weeks of treatment,there was no relapsed patient.Four weeks after the treatment,in FAS the cure rate in test group was significantly higher than that of the control(46.7% vs. 8.9%,P<0.01),while the progression rate was lower than that of the control(11.1% vs. 15.6%,P>0.05).In PPS,the cure rate in test group was significantly higher than that of the control(57.5% vs. 5.1%,P<0.01),while the progression rate was lower than that of the control(7.5% vs.10.3%,P>0.05).Four weeks after the treatment,there was no relapsed patient,either.CONCLUSION: Vaginal capsule probiotics can be used to treat asymptomatic BV with high cure rate,less side effect and low relapse rate.
