Analysis of the influence of different regimens of highly active antiretroviral therapy on maternal and infant outcomes in HIV-infected pregnant women
- Author:
Zheng LI
1
;
Hui-chao LIANG
1
;
Li LIANG
1
;
Yin-huan FAN
1
;
Yan-yan YIN
1
;
Xiao-feng GUO
1
;
Jing LI
1
;
Xing-yan DENG
1
Author Information
- Publication Type:Journal Article
- Keywords: HIV infection; highly active antiretroviral therapy; maternal and infant outcomes
- From: Chinese Journal of Practical Gynecology and Obstetrics 2019;35(07):809-814
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To compare the maternal and infant outcomes of pregnant women infected with human immunodeficiency virus(HIV)treated with different regimens of highly active antiretroviral therapy(HAART).METHODS: For pregnant women infected with the human immunodeficiency virus(HIV)who received antiviral therapy and delivered in the Eighth Peple's Hospital of Guangzhu between May 2015 and June 2018,they will be grouped according to different treatment options. The pregnant women's body weight,CD4+T lymphocytes,white blood cells,hemoglobin,serum albumin,neonatal body weight and adverse pregnancy outcomes were compared and analyzed.RESULTS:(1)There was no significantly statistical difference between the two groups of pregnant women in terms of body weight,white blood cells,hemoglobin or serum albumin(P>0.05).(2)The changes of CD4+T lymphocytes in the two groups of pregnant women before and after treatment were statistically different(P<0.05).(3)There was no significant difference in neonatal weight,gestational age or Apgar score between the two groups(P>0.05).(4)There was no significantly statistical difference in the incidence of premature birth,premature rupture of fetal membrane,low birth weight,low amniotic fluid,fetal malformation or neonatal asphyxia between the two groups(P>0.05).Until December 2018,there were no positive reports of HIVRNA and HIV antibody detection in two groups of infants.CONCLUSION: The two HAART schemes have no significant difference in the influence on nutritional status,immune status or maternal and infant outcomes of HIV-infected pregnant women,and they are both effective and feasible,and vertical transmission of HIV from mother to child can be blocked.
