Study on the expression of antiphospholipid antibody subtypes in primary glomerulopathy

Chuan LIN; Qian-kun ZHANG; Ying CHEN; Fei HAN; Jiang-hua CHEN

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Study on the expression of antiphospholipid antibody subtypes in primary glomerulopathy

Author: Chuan LIN ¹ ; Qian-kun ZHANG ; Ying CHEN ¹ ; Fei HAN ¹ ; Jiang-hua CHEN ¹
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1. Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Institute of Nephrology, Zhejiang University, Key Laboratory of Kidney Disease Prevention and Control Technology Hangzhou 310003, China
Publication Type:Journal Article
Keywords: primary glomerulonephritis; antiphospholipid antibodies; anti-cardiolipin antibodies; anti-β2GP1 antibody
From: Chinese Journal of Practical Internal Medicine 2019;39(03):257-259
CountryChina
Language:Chinese
Abstract: OBJECTIVE: To discuss expression of antiphospholipid antibody subtypes in primary glomerular diseases. METHODS: All1021 cases who were admitted to our center between June 2015 and July 2017 in Kidney Disease Center, First Affiliated Hospital,College of Medicine, Zhejiang Universityhad renal biopsy in our center and they were praved to have primary glomerular diseases(303 cases of membranous nephropathy, 483 cases of IgA nephropathy, 76 cases of mesangial proliferative glomerulonephritis, 119 cases of minimal change nephropathy and 40 cases of focal segmental glomerulosclerosis). The levels of anti-cardiolipin(ACL) antibody subtypes(IgG, IgM and IgA)and anti-β2 glycoprotein 1(β2 GP1) antibody subtypes(IgG, IgM and IgA) were measured and compared.RESULTS: The positive rate of APA in membranous nephropathy group was highest(17.5%) and in minimal change nephropathy was lowest group(11.8%), but there were no significant differences among the groups. The positive rates of ACL in IgA nephropathy and mesangial proliferative glomerulonephritis were 11.4% and 14.5% respectively, which were significantly higher than those of anti-β2 GP1 antibody(P< 0.001, P = 0.009 respectively). The positive rate of anti-β2 GP1 antibody in membranous nephropathy group was 11.2%,significantly higher than that in the other four groups. The positive rate of ACL-IgM in mesangial proliferative glomerulonephritis group was 13.2%, which was significantly higher than that in the other four groups(P< 0.05). The positive rate of ACL-IgA in IgA nephropathy group was 5.8%, which was significantly higher than the other four groups, and there was no statistical difference(P<0.05).CONCLUSION: Antiphospholipid antibody is positive in patients with primary glomerular diseases, and the positive rate of its subtypes varies among the different pathological types of glomerulonephritis, which can be helpful to differential diagnosis and treatment of the disease.