Abnormal coagulation function in myeloproliferative neoplasms
- Author:
Ke ZHU
1
;
Zhuo-gang LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: myeloproliferative neoplasm; coagulation dysfunction
- From: Chinese Journal of Practical Internal Medicine 2019;39(02):132-134
- CountryChina
- Language:Chinese
- Abstract: Myeloproliferative neoplasm is a clonal hematopoietic stem cell disease, which is often complicated by coagulation dysfunction, manifested as thrombosis and bleeding tendency. The mechanism of coagulation dysfunction in myeloproliferative neoplasm is unclear, which may be the result of multiple factors, such as proliferation and activation of leukocyte, abnormality of platelet and its receptors, JAK2V617 F mutation, vWF consumption and drugs. High-risk patients should be assessed to prevent and reduce adverse events.
