Relation between ICOS signaling and Th9 cell polarization in mice infected with Schistosoma japonicum
10.16250/j.32.1374.2017174
- VernacularTitle:ICOS信号与日本血吸虫感染小鼠Th9细胞极化的关系
- Author:
Ting-Zheng ZHAN
1
,
2
;
Hui-Hui MA
1
;
Ting-Ting ZHANG
1
;
Shan-Shan HE
3
;
Jing XU
1
;
Chao-Ming XIA
1
Author Information
1. Department of Parasitology, Medical College, Soochow University, Suzhou 215000, China
2. Department of Parasitology, Guangxi Medical University, China
3. Department of Parasitology, Guangxi Medical University, China
- Publication Type:Journal Article
- Keywords:
Schistosoma japonicum;
Inducible costimulator (ICOS);
Th9 cell;
Flow cytometry
- From:
Chinese Journal of Schistosomiasis Control
2018;30(4):436-439
- CountryChina
- Language:Chinese
-
Abstract:
To detect the expression level of ICOS on Th9 cells in mice infected with Schistosoma japonicum, and investigate the relation between ICOS signaling and Th9 cell polarization.Twenty-five mice with S. japonicum infection were used as models. IL-9+cells in CD4+ T cells and ICOS+ cells in Th9 cells of the mice were detected by flow cytometry 0, 4, 7, 9 weeks and 12 weeks after the infection.Compared with that 0 week after the infection, the proportion of Th9 cells in CD4+ T cells of the mice significantly increased 4, 7, 9, 12 weeks after the infection (all P < 0.05), and the proportion of ICOS+ cells in Th9 cells also markedly improved (P < 0.05).In S. japonicum infection, the ICOS signaling may have a regulatory effect on Th9 cell polarization.
