Recent progress in drug delivery.
10.1016/j.apsb.2019.08.003
- Author:
Chong LI
1
;
Jiancheng WANG
2
;
Yiguang WANG
2
;
Huile GAO
3
;
Gang WEI
4
;
Yongzhuo HUANG
5
;
Haijun YU
5
;
Yong GAN
5
;
Yongjun WANG
6
;
Lin MEI
7
;
Huabing CHEN
8
;
Haiyan HU
9
;
Zhiping ZHANG
10
;
Yiguang JIN
11
Author Information
1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
2. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
3. Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
4. Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China.
5. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
6. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
7. School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.
8. School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
9. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
10. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
11. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
- Publication Type:Journal Article
- Keywords:
Application;
Basic research;
Delivery strategy;
Drug delivery system;
Pharmaceutics
- From:
Acta Pharmaceutica Sinica B
2019;9(6):1145-1162
- CountryChina
- Language:English
-
Abstract:
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015-2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.
