The application of small molecule PROTAC in researches of different targets
10.16438/j.0513-4870.2019-0924
- VernacularTitle:小分子PROTAC在不同靶点研究中的应用
- Author:
Yuan WANG
1
,
2
;
Jing LONG
3
;
Qi CHANG
1
;
Wei-wen HU
4
;
Gao-yun HU
1
;
Qian-bin LI
1
Author Information
1. Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410012, China
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
3. The Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410012, China
4. Pharmaceutical Department, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming 650021, China
- Publication Type:Research Article
- Keywords:
PROTAC;
rug resistance;
nuclear protein;
membrane protein;
cytoplasmic protein
- From:
Acta Pharmaceutica Sinica
2020;55(3):446-452
- CountryChina
- Language:Chinese
-
Abstract:
The protein proteolysis-targeting chimeras (PROTAC) are a kind of bifunctional compound that can recruit target proteins and degrade the enzyme of target proteins. The mechanism of PROTAC is using the ubiquitin-proteasome pathway to degrade target protein specifically. Because of its potential to target non-proprietary proteins and to play roles in drug resistance, PROTAC has attracted wide attention. This review summarizes the application of small molecule PROTAC in previous studies of different targets, such as nuclear proteins, membrane proteins and cytoplasmic proteins.
