Advances in research on the role of nitric oxide in regulating sleep and arousal
10.16438/j.0513-4870.2019-0790
- VernacularTitle:一氧化氮调控机体睡眠觉醒的研究进展
- Author:
Feng-ting YU
1
;
Jian-jun ZHANG
1
Author Information
1. Beijing Key Laboratory of New Drug Mechanism and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
sleep;
arousal;
nitric oxide;
ascending reticular activating system
- From:
Acta Pharmaceutica Sinica
2020;55(3):421-426
- CountryChina
- Language:Chinese
-
Abstract:
Nitric oxide (NO) is widely present in peripheral and central nervous system and regulates many physiological functions. Sleep-arousal is an advanced physiological activity. Studies have shown that NO is involved in the regulation of sleep and arousal. Nitric oxide synthases (NOSs) are a family of enzymes that catalyze the production of NO from L-arginine. Through guanylate cyclase or S-nitrosation of protein, NO can affect the activity of the ascending reticular activating system to regulate the sleep-arousal process. This paper summarizes the production of NO, its effect on sleep-arousal and its mechanism in the ascending reticular activating system, and provides new ideas and directions for the study of sleep and arousal.
