Mediator complexes regulate skeletal muscle metabolic function: a review
10.16438/j.0513-4870.2019-0726
- VernacularTitle:中介复合体对骨骼肌代谢功能影响及机制研究进展
- Author:
Na LI
1
;
Lin YIN
1
;
Xiu-ying YANG
1
;
Guan-hua DU
1
Author Information
1. Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
mediator complex;
mediator;
transcription factor;
skeletal muscle metabolism
- From:
Acta Pharmaceutica Sinica
2020;55(3):407-412
- CountryChina
- Language:Chinese
-
Abstract:
Mediator complexes involved in skeletal muscle metabolic processes have become a hot research topic in recent years. The mediator complex is a multi-protein complex which participates in transcription by bridging specific transcription factors and basal transcriptional machinery (RNA polymerase II). Mediator complexes are involved in regulating the expression of transcription factors related to skeletal muscle metabolism and muscle fiber transformation, such as PPARs and PGC1α. These mediators participate in skeletal muscle glucose metabolism by regulating glucose transporter GLUT4 and key transcription factors of metabolic pathways. In addition, they regulate metabolic diseases by regulating the expression of PPARγ, UCP-1 and other genes involved in skeletal muscle lipid metabolism and mitochondrial functions. This article reviews the mechanism and effects of mediator complexes on skeletal muscle metabolism.
