Research progress of cGAS-STING in tumor metastasis

VernacularTitle:cGAS-STING在肿瘤转移中的研究进展
Author: Shu-mei TU ^{1
,

2} ; Yu-ping LIU ^{1
,

2} ; Yan CHEN ^{1
,

2}
Author Information

1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
Publication Type:Research Article
Keywords: cGAS-STING; DNA; tumor; metastasis; immune; agonist; inhibitor
From: Acta Pharmaceutica Sinica 2020;55(3):398-406
CountryChina
Language:Chinese
Abstract: Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signaling pathway as an essential immune response pathway in cytoplasm, can find cytoplasmic DNA to regulate the innate immune and adaptive immune response. Studies have shown that the signaling pathway can be activated by both tumor self-DNA and genomic instability, thus to promote or inhibit the development and metastasis of tumors. Therefore, the role of cGAS-STING in tumor genesis, development and metastasis will be systematically expounded from the structures, physiological functions, inhibitors and agonists of cGAS and STING as well as its pathway transduction regulation in this paper. The paper aims to offer theoretical basis and reference for targeting cGAS-STING anti-tumor drugs in clinical practice and cancer clinical and cancer research workers.